Table 2.
The table shows the transcripts that differed by >2.0 fold with p < 0.05 in inflamed mucosa (IM) vs. noninflamed mucosa (NM) in UC and CD patients. Genes are arranged by alphabetic order. Italic fonts indicate genes differentially expressed only in IM from UC.
| Gene | Description | UC | CD | ||
|---|---|---|---|---|---|
| Paired IM vs. NM | Paired IM vs. NM | ||||
| FC | p value | FC | p value | ||
| C3 | Complement C3 | 5.48 | 0.0106 | ||
| C4BPB | Complement component 4 binding protein beta | 5.86 | <0.0001 | 2.98 | 0.0090 |
| CCL11 | C-C motif chemokine ligand 11 | 2.01 | 0.0121 | 2.27 | 0.0045 |
| CCL20 | C-C motif chemokine ligand 20 | 4.05 | 0.0003 | ||
| CD55 | CD55 molecule (Cromer blood group) | 3.63 | <0.0001 | ||
| CHI3L1 | Chitinase 3 like 1 | 16.96 | 0.0045 | 4.19 | 0.0328 |
| CR2 | Complement C3d receptor 2 | 7.00 | 0.0150 | ||
| CXCL1 | C-X-C motif chemokine ligand 1 | 17.99 | <0.0001 | 6.82 | 0.0413 |
| CXCL10 | C-X-C motif chemokine ligand 10 | 3.23 | 0.0008 | ||
| CXCL11 | C-X-C motif chemokine ligand 11 | 8.93 | 0.0001 | 4.32 | 0.0380 |
| CXCL2 | C-X-C motif chemokine ligand 2 | 14.98 | <0.0001 | ||
| CXCL3 | C-X-C motif chemokine ligand 3 | 9.79 | <0.0001 | ||
| CXCL9 | C-X-C motif chemokine ligand 9 | 5.16 | 0.0002 | 5.22 | 0.0059 |
| CXCR1 | C-X-C motif chemokine receptor 1 | 19.22 | 0.0131 | ||
| EDN3 | Endothelin 3 | −2.92 | 0.0048 | ||
| FPR1 | Formyl peptide receptor 1 | 10.57 | 0.0035 | ||
| IFNG | Interferon gamma | 2.82 | <0.0001 | ||
| IL1RN | Interleukin 1 receptor antagonist | 8.15 | 0.0018 | 5.68 | 0.0498 |
| IL23A | Interleukin 23 subunit alpha | 3.11 | <0.0001 | ||
| IL2RA | Interleukin 2 receptor subunit alpha | 3.45 | 0.0006 | ||
| CXCL8 | C-X-C motif chemokine ligand 8 | 19.40 | 0.0185 | ||
| ITGB2 | Integrin subunit beta 2 | 2.31 | 0.0003 | ||
| LCN2 | Lipocalin 2 | 13.05 | 0.0003 | ||
| LTB | Lymphotoxin beta | 4.01 | 0.0007 | ||
| LYZ | Lysozyme | 2.06 | 0.0009 | 2.16 | 0.0344 |
| MMP1 | Matrix metallopeptidase 1 | 9.98 | 0.0108 | ||
| MMP10 | Matrix metallopeptidase 10 | 14.92 | 0.0004 | ||
| MMP3 | Matrix metallopeptidase 3 | 30.01 | 0.0016 | ||
| MMP7 | Matrix metallopeptidase 7 | 37.37 | 0.0036 | 6.00 | 0.0098 |
| NOS2 | Nitric oxide synthase 2 | 10.99 | 0.0005 | ||
| PCK1 | Phosphoenolpyruvate carboxykinase 1 | −6.29 | 0.0002 | ||
| PECAM1 | Platelet endothelial cell adhesion molecule 1 | 2.42 | 0.0046 | ||
| REG1A | Regenerating family member 1 alpha | 10.11 | 0.0123 | ||
| S100A8 | S100 calcium binding protein A8 | 17.91 | 0.0018 | ||
| S100A9 | S100 calcium binding protein A9 | 9.31 | 0.0005 | ||
| SAA1 | Serum amyloid A1 | 62.83 | 0.0016 | ||
| SELL | Selectin L | 5.31 | <0.0001 | ||
| SOD2 | Superoxide dismutase 2 | 2.14 | 0.0003 | 2.03 | 0.0429 |
| STAT1 | Signal transducer and activator of transcription 1 | 2.26 | <0.0001 | ||
| TDO2 | Tryptophan 2,3-dioxygenase | 4.00 | <0.0001 | ||
| TFF1 | Trefoil factor 1 | 2.74 | 0.0001 | ||
| TIMP1 | TIMP metallopeptidase inhibitor 1 | 4.48 | <0.0001 | ||
| TNF | Tumor necrosis factor | 2.58 | 0.0022 | ||
| UBD | Ubiquitin D | 7.95 | 0.0002 | 2.92 | 0.0116 |