Figure 2.

IFNL4 genotypes and gene expression in peripheral blood during chronic HCV infection. (A,B) Volcano plot showing change in overall gene expression in peripheral blood between non‐CC patients and healthy controls (A) and direct comparison between non‐CC versus CC patients (B) Log2 fold change is plotted along the X‐axis and the P value along the y‐axis. The dotted red line shows the threshold of significance (P < 0.05). Genes labeled in the figure are those that were validated by real‐time PCR. (C,D) GSEA analysis showing enrichment of IFNα/β gene set in non‐CC versus control (C) and a similar comparison of genes comparing non‐CC versus CC patients. (E) IFNL4 genotypes and pathway analyses during chronic HCV infection: over‐representation analysis of reactome pathways on the list of up‐regulated genes between non‐CC versus CC patient groups. The Y‐axis shows the top six pathways (significance is color coded) X‐axis shows the proportion of gene in each pathway compared to the total list of genes. The size of the circles represent the gene counts in the pathway.