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. 2018 Sep 15;68(3):859–871. doi: 10.1002/hep.29877

Figure 4.

Figure 4

IFNL4 genotypes and RNAseq analysis in liver of HCV patients. (A) Reactome pathways enrichment analysis on differentially up‐regulated list of genes obtained by RNAseq analysis between non‐CC versus CC patients. Criteria for inclusion were a minimum of 1 lfc (log 2 fold change) in expression and P value <0.05. The size of circles reflects the gene count in the pathway, the X‐axis represent the gene ratio (N genes in pathway/n genes in the entire list of genes), and the color of the circles reflects the adjusted P value. (B) IFNL4 genotypes and cytoband analysis in liver of HCV patients: expression graph of chromosomally sorted genes in cytoband 19q13.2. Lines across the graph represent average gene expression in each IFNL4 genotype (TT in red, black dotted lines CT, and black solid line represent expression in CC groups). IFNL3/4 gene is not shown because the genes included in the graph are those that have an average gene expression of log2 cpm >2. (C,D) GSEA showing enrichment of IFNα and IFNL Huh‐7 signature gene (uniquely up‐regulated genes when Huh7 cells are stimulated by IFNα or IFNL3) on non‐CC versus CC gene list in liver. Abbreviations: MDA5, melanoma differentiation‐associated gene 5; RIG‐I, retinoic acid‐inducible gene I.