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. 2018 Oct 30;9:2041731418808695. doi: 10.1177/2041731418808695

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© The Author(s) 2018

This article is distributed under the terms of the Creative Commons Attribution 4.0 License (http://www.creativecommons.org/licenses/by/4.0/) which permits any use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figure 4. — Transwell migration of hMSCs tagged with magnetic nanoparticles. PKH26-labelled mesenchymal stem cells (hMSCs) (10³ cells) were placed in the upper chamber of FluoroBlok transwell and migration across the membrane was quantified after 96 h. The relative migration of hMSCs labelled with either unconjugated (blank) or TREK1-targeting nanoparticles was compared to unlabelled cells (control) and unlabelled cells exposed to the magnet. High concentration foetal calf serum (30% FCS) served as the positive control. All groups exposed to the nanoparticles or the magnetic array showed a slight (non-significant) increase in migration over the control, and the TREK1-stimulated group (highlighted red) showed significantly increased migration (p = 0.02) over the control. Bars represent the experimental mean, and error bars show standard deviation, n = 6. *p < 0.05 and ***p < 0.001.