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. 2018 Oct 24;10:317. doi: 10.3389/fnagi.2018.00317

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Copyright © 2018 Le, Kuplicki, McKinney, Yeh, Thompson, and Paulus.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Relationship between age-covariate correlation and the difference in measured correlation. The difference between using BrainAGE and BrainAGER depends on the age-covariate relationship. (A) Covariate-BrainAGER correlations as a function of the covariate-BrainAGE correlation, with points colored according to the Age-Covariate correlation. The 45-degree line is shown, and covariates more strongly related to age are further from the line. (B) The squared difference in r between using BrainAGE and BrainAGER as a function of the variance explained by age.