Table 1.
Participating Healthcare Systems and Lynch Syndrome Screening by Clinical Site
| Lynch Syndrome Screening Program Typea | |||||||
|---|---|---|---|---|---|---|---|
| CRC Tumor Screeningb | EC Tumor Screeningc | ||||||
| Healthcare System | Clinical Site (State) | No Program | CRC age cutoff | BRAF Reflex | PHM Reflex | EC age cutoff | PHM Reflex |
| Geisinger | Geisinger (PA) | All ages | X | X | All ages | X | |
| Kaiser Permanente (KP) | KP-Colorado (CO) | X | |||||
| KP-Northwest (OR/WA) | All ages | X | X | All ages | X | ||
| Sutter Health (SH) | SH-Palo Alto Medical Foundation (CA) | X | |||||
| Meyers Primary Care Institute (MCPI) | Reliant Medical Group (MA) | All ages | |||||
| HealthPartners | HealthPartners (MN) | All ages | X | X | All ages | X | |
| Harvard Pilgrim Healthcare | Harvard Pilgrim (MA) | X | |||||
| Catholic Health Initiatives (CHI) | Franciscan (WA) | All ages | X | X | All ages | X | |
| Tri Health (OH) | All ages | X | X | All ages | X | ||
| Mercy Des Moines (IA) | All ages | X | X | All ages | |||
| Kentucky One (KY) | All ages | ||||||
| Chattanooga (TN) | All ages | X | X | All ages | X | ||
| Good Samaritan (NE) | X | ||||||
| Lincoln (NE) | < 70 years | X | |||||
| St. Francis (NE) | X | ||||||
| St. Joes Bryan (TX) | X | ||||||
| St. Vincent (AR) | X | ||||||
| Centura (CO) | < 70 years | < 60 years | |||||
| Alegent Creighton (OH) | X | ||||||
| St. Alexius (ND) | X | ||||||
| Mercy (ND) | X | ||||||
aRecommendation: screen all Colorectal cancer (CRC) and Endometrial Cancer (EC) tumors for mismatch repair deficiency
bRecommendation: reflex test positive screens for BRAFV600E point mutation and MLH1 Promoter Hypermethylation (PHM) testing to rule out somatic loss of function (sporadic cancer)
cRecommendation: reflex test positive screens for PHM to rule out somatic loss of function (sporadic cancer)