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. 2018 Oct 30;11:776. doi: 10.1186/s13104-018-3886-4

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© The Author(s) 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — Antithrombotic effect of TAK-442 in a modified rabbit arteriovenous shunt thrombosis model. In a rabbit model of arteriovenous shunt thrombosis stimulated with a thrombogenic silk thread soaked with recombinant human tissue factor, the thrombus-coated thread was weighed 15 min after shunt placement at each dose. The drug was administered as a bolus (two-thirds of total dose) followed by constant intravenous infusion (one-third of total dose) for 30 min prior to shunt placement. Data are expressed as mean ± standard error of the mean; n = 4 animals per treatment group. *P ≤ 0.025 versus vehicle (one-tailed Williams’ test)