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. 2018 Oct 31;17:401. doi: 10.1186/s12936-018-2543-7

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© The Author(s) 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — Multivariate correlation coefficients and networks in infected and non-infected individuals from Itaituba. Spearman’s correlation was applied to assess the association between the PvRON2 reactivity index with age, parasitaemia, platelets, RBC, hematocrit, hemoglobin, IL-6, IL-2, IL-10, IL-4, TNF-α and IFN-γ, and correlation networks were generated by the analysis of the relationship among each mediator measured in the plasma samples in a, b the infected group and c, d the non-infected group. Each connecting line (edge) represents a significant interaction (p < 0.05) detected by the network analysis using the R software. Correlation strength is represented by the tile or edge color transparency and width. Positive correlations are represented with red tiles/edges, and negatives correlations are represented with by blue tiles/edges