Fig. 3.

Mutation burden in BRCA1- and BRCA2-mutated HGSOC. a Comparison of somatic mutation burden between wild-type (no mutations detected, n = 27), BRCA1 (n = 7), and BRCA2 (n = 7)-mutated (germline and somatic) HGSOC in our study. b Comparison of somatic mutation burden between wild type (n = 40), BRCA1 (n = 5) and BRCA2 (n = 3) mutated (germline and somatic) in short- and long-term exceptional surviving HGSOC from the TCGA ovarian serous cystadenocarcinoma study. Mutation burden for each individual in each group is shown in increasing order. The patient with the highest mutation burden in the BRCA1-mutated group also has biallelic MLH1 loss. Data points are colored by group, wild-type in black, BRCA1-mutated in dark-blue, and BRCA2-mutated in light-blue. Groups are sorted by increasing median mutation burden. Boxplot for each group shows the group summary statistics for each survival group. Statistical significance is tested by non-parametric 2-sided Wilcoxon rank test for non-paired data and raw p value is reported. n.s. p > 0.05