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. 2018 Oct 30;18:38. doi: 10.1186/s12880-018-0280-6

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 6 — Neuroanatomical differentiation of both ex vivo and in vivo micro-CT scan are enhanced by NLM denoising. The original (Aa) and denoised (Ba) ex vivo scans illustrate sharper periventricular edges seen in (Ba) while gross neuroanatomical details are preserved in both. The difference in image noises is more obvious when comparing the respective magnified views, (Ab) and (Bb). Similar but more prominent edge enhancements is shown by the comparison of (Ca) and (Da), original and denoised in vivo micro-CT scans, respectively. The markedly improved signal-to-noise ratio is easily appreciated in the magnified denoised (Db) from the original (Cb) views. The respective grayscale line profile of each scan revealed reductions in intensity variability in denoised group, (Bc) and (Dc), in comparison to the originals, (Ac) and (Cc)