Table 4.

Imaging recommendations for EPAD longitudinal cohort study

Imaging technique	Baseline	Baseline use	Follow-up	Follow-up use	Measures
3D T1	Standard	Exclusion criteria Volumetric analysis Visual rating pathology Identify increased risk of decline	Annually	New incidental findings Atrophy rates Track visual pathology Identify increased risk of decline	Volumetric analysis: brain structures Visual: lacunes, atrophy
3D FLAIR	Standard	Exclusion criteria Volumetric analysis Visual rating pathology Subject stratification	Annually	New incidental findings Track visual pathology	Volumetric analysis: white matter hyperintensities Visual: lacunes, white matter hyperintensities, ARIA
2D-T2	Standard	Exclusion criteria Visual rating pathology	Annually	New incidental findings Track visual pathology	Visual: lacunes, perivascular spaces, ARIA
2D-T2* 3D-T2*/ SWI	Standard Optional	Exclusion criteria Visual rating pathology	Annually	New incidental findings Track visual pathology	Visual: microbleeds and superficial siderosis
DTI	Optional	Exploratory analysis	Optional 2-year	Changes in measures	Axial and radial diffusivity
ASL	Optional	Exploratory analysis	Optional 2-year	Changes in measures	Whole brain and regional perfusion
rs-fMRI	Optional	Exploratory analysis	Optional 2-year	Changes in measures	Connectivity measures
Amyloid PET (static and dynamic)	Optional	Inclusion criteria	Optional	Changes in measures	Visual: amyloid positive Quantitative measures of amyloid pathology Dynamic scanning: perfusion measures

ARIA Amyloid-related imaging abnormalities, ASL arterial spin labelling, DTI diffusion tensor imaging, EPAD European Prevention for Alzheimer’s Dementia, FLAIR fluid attenuated inversion recovery, PET positron emission tomography, rs-fMRI resting state functional magnetic resonance imaging