Fig 3.

Graph of rectal temperature vs time for 10 MHS-Hom (5F, 5M), 10 MHS-Het (5F, 5M) and eight MHN (4F, 4M) animals exposed 2 vol% halothane. Neither MHS-Hom nor MHS-Het animals survived the exposure, but there was a significant difference between time to death and time of exposure between MHS-Hom and MHS-Het. There was no significant difference between males and females in either genotype. None of the MHN animals showed a significant increase in body temperature during the 80 min exposure time and all completed the experiment unharmed. MH, malignant hyperthermia; MHN, MH normal; MHS-Hom, homozygous MHS; MHS-Het, heterozygous MHS.