Gene expression moderation of prenatal depression on Negative Affectivity. Solid line represents high gene expression (+1 SD), and dashed line represents low gene expression (−1 SD). Prenatal maternal depression is linked to higher levels of Negative Affectivity only among infants with the low levels of placental gene expression (p values < .001, =.004, and .007 for HSD11B2, NR3C1, and NR3C2, respectively), but not high levels of gene expression (p values = .698, .817, and .589 for HSD11B2, NR3C1, and NR3C2, respectively). Figures are based on the fully adjusted analyses.