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. 2018 Oct 31;9:4552. doi: 10.1038/s41467-018-06968-7

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — PRMT2-mediated H3R8me2a is important for the maintenance of active promoters and enhancers. a Average profiles of indicated histone modifications across a genomic window of ± 5000 bp surrounding the H3R8me2a peak summit (top panel). Heatmaps of indicated histone modifications across regions of ± 5000 bp surrounding the H3R8me2a peak summit in each cluster. According to H3R8me2a peak distribution, H3R8me2a peaks are divided into three clusters (promoter, distal, gene body) (bottom panel). H3R8me2a peak number in promoter region = 1793, in distal region = 5247, in gene body region = 5947. b Average profiles of H3K27ac, H3K4me3, and H3K4me1 across a genomic window of ± 3000 bp surrounding the PRMT2-dependent H3R8me2a peak (6698 peaks) summit. c Genomic snapshots of ChIP-seq analyses for H3K4me3, H3K27ac, H3K4me1, and HER8me2a in U87 cells transduced with shScr (upper track) and shPRMT2 (lower track). d ChIP-qPCR analysis of H3K4me3, H3K4me1, H3K27ac, and H3R8me2a enrichment on the promoter or enhancer regions of PRMT2 target genes. GAPDH promoter serves as a negative control (error bars, mean ± SD; n = 3)