Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2018 Oct 31;9:4548. doi: 10.1038/s41467-018-06979-4

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 1 — Protein corona shield nanoparticle (PCSN). a We introduce the protein corona shield (PCS) concept for an efficient target drug delivery system. Generally, nanoparticle drug carriers with a target ligand lose their targeting ability on being coated by blood proteins in a biological environment. However, the PCS system can inhibit blood protein adsorption to maintain the targeting ability and avoid unwanted clearance by the mononuclear phagocyte system. b Mass spectrometry analysis of the GST-HER2-Afb showed a mass of 36.3 kDa. c Zeta-potential analysis of mesoporous silica nanoparticle (MSN) (−23 mV), GSH-MSN (−39 mV), GST-HER2-Afb (−5.25 mV), and PCSN (−5.3 mV). d Size distribution plots of PCSN. e Images of cellular uptake of fluorescein 5 maleimide-modified GST-HER2-Afb by the target cell (SK-BR3) and the negative control (MCF-10A). f Transmission electron microscopic images of GSH-MSN and PCSN (scale bar represents 100 nm). All bar graphs were reported as means ± standard deviations (SDs) for three experimental replicates (n = 3)