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. 2018 Oct 31;9:4548. doi: 10.1038/s41467-018-06979-4

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — Ex vivo and in vivo efficiency of PCSN. a, b Fluorescence images of organs and tumors 48 h after intravenous injection and biodistribution of injected formulations in animals with SK-BR3 tumor xenograft from fluorescence intensity analysis. In vivo antitumor effects in different treatment groups loaded with camptothecin (CPT) (1.5 mg/kg of mice) (scale bar is 2 cm). c Growth curve of tumor volume after intravenous injection with various groups of carriers until day 21 (n = 6 mice per group, mean ± 1 day [n = 6 mice per group, mean ± SD, statistical significance was calculated by one-way analysis of variance, *P < 0.05, **P < 0.01]