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. 2018 Oct 31;8:16122. doi: 10.1038/s41598-018-34205-0

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Sub-acute repeat dose and skin safety in rats (5 mg/kg FA dose/daily for 4 weeks) and Dermatological safety evaluation in 25 humans (Single application of RDA dose 400 µg/person). (a) Plasma profile in normal rats with significant folate levels due to Nutricosmetics. (b) Erythrocyte folate levels. (c) Skin folate levels showing reservoir of FA after 4 weeks. (d) Liver folate levels shows no toxicity in liver. (e) No significant Silicon levels(ppm) in plasma after 28 days daily FAL-MM application proves safety of FAL-MM. (f) Histopathology of H&E stained organs of rats sacrificed after 4 weeks observed under 10X. Normal group given regular diet throughout study whereas other groups were given folate deficient diet though out the study duration (a–f) N = 6 Mean ± SD ***P < 0.001, **P < 0.05 and *P < 0.01, Student’s t-test. (g) Skin compatibility dermatological evaluated of Nutricosmetics in humans shows no irritation potential for topical application in human volunteers.