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. 2017 Nov 27;9(11):909–929. doi: 10.1007/s13238-017-0490-7

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© The Author(s) 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Schematics of the pathfinding of thalamocortical axons after knocking out genes related to guidance cues. (A) Normal development of thalamocortical axon pathfinding from E14.5 to P0. (B1–3) Phenotypes of thalamocortical axons after knocking out TC axon guidance cues including Semaphorin-6A and Lhx2. (C1–7) Phenotypes of thalamocortical axons after knocking out TC pathway intrinsic cues including Ebf1, Dlx1/2, p75NTR, Coup-tfI, Emx2, Pax6, Celsr3 and Rfx3. (D1–2) Phenotypes of thalamocortical axons after knockout of topographic mapping cues such as ephrin-A5; EphA4 and Ngn2. Red dots represent dLGN projecting neurons. Red lines stand for TC axons