Table S2.
Adjusted ORs and 95% CIs of acute pancreatitis for current use of oral metronidazole (<31 days before index date)
| Analysis | Adj OR (95% CI)a |
|---|---|
| Main | 8.22 (5.32–12.68) |
| Supplementary | |
| Reclassifying former exposure to metronidazole as unexposed | 8.15 (5.28–12.59) |
| Restriction to individuals with index dates between 2007 and 2008 | 8.98 (5.26–15.35) |
| By number of metronidazole prescriptions before index date | |
| Single prescription | 8.63 (5.11–14.57) |
| Multiple prescriptions | 7.31 (3.35–15.94) |
| By sex | |
| Men | 11.39 (6.28–20.65) |
| Women | 5.61 (2.93–10.73) |
Notes: ORs and 95% CIs were estimated using subjects not exposed to metronidazole before index date as the reference group.
a
Adjusted for matching variables (sex, age at index date, and calendar year at index date), inflammatory bowel disease, thiopurine drugs, sulfasalazine, alcohol abuse, cholelithiasis, civil status, education level, country of birth, chronic obstructive pulmonary disease, diabetes, gastrointestinal ulcer, PPIs, H2-receptor blockers, nonsteriodal anti-inflammatory drugs, opioid analgesics, and polypharmacy score.
Abbreviations: Adj, adjusted; CI, confidence interval; OR, odds ratio; PPI, proton pump inhibitor.