Table 4. Diagnostic performance of AFP & Lamin B1 among different studied groups.
| Parameter | Group/stage | Best cut-off | SN% | SP% | PPV% | NPV% | Eff% |
|---|---|---|---|---|---|---|---|
| AFP (ng/dl) | Group I vs II/III | 5.0 | 80 | 90 | 92.3 | 75 | 84 |
| Stage 0 vs Group II | 3.5 | 78.6 | 60 | 73.3 | 66.7 | 70.8 | |
| Stage 0 vs group A | 142 | 71.4 | 92.9 | 83.3 | 86.7 | 85.7 | |
| Lamin B1 (2 −ΔΔCq) | Group I vs II/III | 1.4 | 100 | 90 | 93.4 | 100 | 96 |
| Stage 0 vs Group II | 1.3 | 100 | 90 | 93.3 | 100 | 95.8 | |
| Stage 0 vs A | 2.8 | 100 | 92.9 | 87.5 | 100 | 95.2 | |
| AFP (ng/dl) and
Lamin B1 (2 −ΔΔCq) |
Group I vs II | 3.5(ng/dl) +
1.4(2 −ΔΔCq) |
100 | 100 | 100 | 100 | 100 |
SN%, sensitivity; SP%, specificity; PPV%, positive predictive value; NPV%, negative predictive value; EFF%, efficacy; AFP, α-fetoprotein.