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LAT-mediated uptake of [14C]L-leucine and pregabalin
| [14C]L-Leucine uptake (μL/mg-protein) | Pregabalin uptake (μL/mg-protein) | |
|---|---|---|
| Mock | 247 ± 5 | 22.2 ± 1.9 |
| LAT1 | 485 ± 29* | 57.2 ± 1.7* |
| LAT2 | 345 ± 13* | 21.4 ± 0.9 |
LAT1-, LAT2-overexpressing, and mock cells were incubated with [14C]L-leucine (0.4 μM) or pregabalin (10 μM) at 37°C for 2 or 5 min, respectively. Each value represents the mean ± SEM (n = 3). *p < 0.05, significantly different from mock cells
