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. 2018 Aug 22;136(5):709–727. doi: 10.1007/s00401-018-1900-5

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© The Author(s) 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 4 — Network plots for Cohort A co-expression modules 2, 3 and 13. Genes that have a module membership (MM) > 0.7 and are amongst the top 150 connections, based on their degree of correlation in the TOM matrix, are shown for CohortA_M2 a, CohortA_M3 b and CohortA_M13 c. The size of the nodes reflects the number of connections (edges) and the weight of the edges reflects the strength of correlation between two nodes. Nodes are shaped according to the most significant neuropathological trait (bottom right legend) and colored according to whether they are predominantly expressed in one CNS cell type (top right legend)