Table 2.

Goeman’s global testing of differences in metabolic pathways (Table 1) between lean and obese volunteers and the effect of a WL intervention [compared to a control (CRT) intervention]

Pathways and number of metabolites		Fasting		Response
		T0	∆T0	iAUC	∆iAUC
		Obese versus lean	WL versus CRTL	Obese versus lean	WL versus CRTL
TCA cycle	8	0.01	0.2	0.4	0.3
BCAA catabolism	7	0.02	0.02	0.5	0.5
Fatty acid oxidation	16	0.07	0.4	0.7	0.5
Lactate pathway	3	0.06	0.5	0.03	0.3
Arg, Pro	6	0.5	0.1	0.02	0.6
Phe, Tyr	2	0.01	0.03	0.3	0.3
Enzymatic oxidation of arachidonic acid	5	0.6	0.5	0.3	0.09

Differences were tested for fasting state values (T0) and postprandial response (iAUC)