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. 2018 Jul 21;75(23):4341–4356. doi: 10.1007/s00018-018-2875-z

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© The Author(s) 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 4 — Ultrastructural analysis of Mef2 > Venus, Mef2 > Hsp67BcWT-Venus, and Mef2 > Hsp67BcR126E-Venus D. melanogaster larval muscles. a TEM analysis of Mef2 > Hsp67BcWT-Venus ventral longitudinal VL4 sarcomeres. Yellow double-ended arrows indicate regular distances between Z-lines traced by the red-dashed line. An asterisk indicates small deposits of glycogen granules, Scale bar: 1 μm. The inset shows muscle with functional mitochondria (red arrowheads). Scale bar: 0.4 μm. b TEM analysis of Mef2 > Venus ventral longitudinal VL4 sarcomeres. Yellow double-ended arrows indicate regular distances between Z-lines traced by red-dashed lines. An asterisk indicates small deposits of glycogen granules. Z-lines traced by red-dashed lines, and an asterisk indicates small deposits of glycogen granules. Scale bar: 1 μm. c TEM analysis of Mef2 > Hsp67BcR126E-Venus ventral longitudinal VL4 sarcomeres. Yellow double-ended arrows indicate interrupted and improperly placed Z-lines traced by the red-dashed lines. Asterisks indicate excessive accumulation of glycogen granules around the mitochondria and among sarcomeric units. Scale bar: 1 μm. d TEM analysis of Mef2 > Hsp67BcR126E-Venus ventral longitudinal VL4 sarcomeres. Asterisks indicate excessive accumulation of glycogen granules around the mitochondria and among sarcomeric units. Accumulation of disrupted mitochondria occurred in the subsarcolemmal sarcoplasm (encircled with green-dashed line). Scale bar: 1 μm. e TEM analysis of Mef2 > Hsp67BcR126E-Venus ventral longitudinal VL4 sarcomeres. Asterisks indicate excessive subsarcolemmal accumulation of glycogen granules around the mitochondria and among sarcomeric units, the membrane-bound autophagosomes containing glycogen (yellow arrowhead). Scale bar: 1 μm. The inset shows muscle with abrupt mitochondria characterized by the presence of broken cristae (red arrowheads). Scale bar: 0.4 μm. f TEM analysis of Mef2 > Hsp67BcR126E-Venus ventral longitudinal VL4 sarcomeres. Yellow double-ended arrows indicate interrupted and improperly placed Z-lines traced by the red-dashed lines. Asterisks indicate excessive accumulation of glycogen granules around the mitochondria (red arrowheads) and among sarcomeric units. Scale bar: 1 μm