Fig. 6.
Comparison of initiator tRNA carriers. a Structural and functional domains in eIF2A. WD-repeat sequences and α-helical regions are depicted as closed boxes and open circles, respectively. b Ribbon diagram showing IF2 (magenta) complexed with fMet-tRNAMeti, as previously reported by Allen et al. (PDB: 1ZO1) [59]. c Model of the eIF5B/eIF2A/Met-tRNAMeti complex. The structure of eIF2A (blue) was predicted using the Phyre2 server [60] and visualized with the PyMOL program [35]. The structures of eIF5B (magenta) and Met-tRNAMeti were previously reported by Fernandez et al. (PDB: 4BYX) [14]. d Evolutionary perspective on the initiator tRNA carriers. The initiator tRNA carrier homologs and their functions are depicted