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. 2018 Jul 30;45(13):2396–2403. doi: 10.1007/s00259-018-4088-y

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© The Author(s) 2018

Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 2 — A 60-year-old man with grade IV glioma. Axial T1-weighted MRI showed the lesion in the left frontal-temporal lobe with enhancement (a). The tumor lesion was highly positive in [¹²³I]-VEGF SPECT imaging (the T/N ratio = 2.80) before the radiation therapy (b). Reduced [¹²³I]-VEGF accumulation in the tumor region (the T/N ratio = 1.78) was found after the radiation therapy (c). White arrows indicate the tumor region