Fig. 4.

Complex spike-coupled changes in SS encoding. a Purkinje cell SS firing maps (mean-subtracted) with hand velocity (VX and VY) reveal an increased modulation with VY after CS occurrence (t = 0 msec). The SS modulation with each parameter before and after the CS discharge was quantified with a regression analysis in which the coefficient of determination, R², provides a measure of SS encoding strength and the regression coefficient, β, a measure of SS sensitivity (see Methods in [69]). b Plotted for this example Purkinje neuron is the pre- (blue trace) and post-CS (red trace) R² plot that highlights the increase in SS modulation with VY following CS occurrence. Note the step changes between blue and red traces. c Plot of pre- (blue trace) and post-CS (red trace) SS sensitivity relative to VY demonstrates a corresponding increase after CS occurrence. Plots in b and c from the same cell shown in a. d Plot of change in position error relative to CS occurrence (post-pre) with the strength (defined by R²) of CS-coupled changes in SS encoding for the population of Purkinje cells. Magnitude of position error decreases as the SS encoding of error increases (modified with permission from [69])