. 2018 Oct 25;11:1959–1974. doi: 10.2147/IDR.S172366

Table 2.

Recommendations for antibiotic treatment of methicillin-resistant Staphylococcus aureus complicated skin and soft tissue infections

Guidelines	Infection	Recommended therapy
Infectious Diseases Society of America³¹	cSSTI (deeper soft-tissue infections, surgical/traumatic wound infection, major abscesses, cellulitis, and infected ulcers and burns) Non-purulent cellulitis	• Surgical debridement • Vancomycin, linezolid, daptomycin, telavancin, clindamycin • β-lactam antibiotic active against MRSA
Surgical Infection Society¹¹⁸	Complex abscesses with cellulitis and polymicrobial cSSTIs	• Incision and drainage (in case of abscess) • Vancomycin, clindamycin, linezolid, or erythromycin
Gruppo Italiano di Studio sulle Infezioni Gravi⁴¹	MRSA-related cSSTIs and severe surgical infections	• Use of TNP/VAC (for deep surgical infections) • Vancomycin, teicoplanin, linezolid, tigecycline, daptomycin
Italian Society of Infectious Diseases and international Society of Chemotherapy¹¹⁹	MRSA-related cSSTIs	• Early surgical treatment wherever feasible • Vancomycin, teicoplanin, linezolid, tigecycline, daptomycin
Spanish Society of Chemotherapy³⁵,¹²⁰ British Society of Antimicrobial Chemotherapy¹²¹	MRSA-related cSSTIs Severe cSSTI with MRSA	Linezolid, daptomycin, vancomycin, teicoplanin Linezolid, daptomycin, vancomycin, teicoplanin

Abbreviations: cSSTIs, complicated skin and soft tissue infections; MRSA, methicillin-resistant Staphylococcus aureus; TNP/VAC, topical negative pressure/vacuum-assisted closure.