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. 2018 Jun 19;46(11):1857–1869. doi: 10.1007/s10439-018-2063-1

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© Biomedical Engineering Society 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Diffusion loading of VS55 with variable rewarming success in arteries. (a) Historical microCT data of VS55 loading into a carotid artery (0.8-mm thick) at 18 min,18 used to extract VS55 diffusivity. (b) Predicted temporal and spatial concentration profiles of VS55 with extracted diffusivity and normalized boundary conditions for the same artery at 15, 30 and 60 min. (c) Predicted temporal and spatial concentration profiles of VS55 in thicker 2 mm aorta at 15, 30 and 60 min. (d) Historical data18 post nanowarming in carotid artery and aorta with convection and nanowarming. The viability is reduced for aorta compared to femoral (29 ± 8.2% vs. 90.5 ± 7.4%, *** p < 0.001) or to carotid (29 ± 8.2% vs. 91.5 ± 2.4%, *** p < 0.001), where n = 3–6 is the number of independent experiments, and n = 4–7 is the number of segments tested.