Fig. 2.

miR-200b and miR-429 are upregulated in response to hypoxia. a The schematic representation of the interaction of the miR-200b/200c/429 seed sequence with the predicted target sequence (TS) in the NOS3 3′UTR sequence. As indicated by shading, the miR-200b, miR-200c, and miR-429 share high sequence homology. b HUVECs were exposed to hypoxia for the times indicated and total RNA enriched in miRNAs was isolated. miR-200b, mir-200c, and miR-429 levels were quantified by qPCR and normalized to RNU44. Data represent the mean ± SD of three independent experiments. *p < 0.05 was considered significant