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Schematic representation of the proposed model of signaling via Fzd5 in ECs. Our data provide evidence for a new proposed model of signaling in ECs in the absence of Fzd5. Knockdown of this receptor provokes its ligand Wnt5a to signal via an alternative receptor, thereby triggering the activation of nPKC/Ets1-mediated transcription of vascular regression-associated factors, among which Flt1 and Angpt2
