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. 2018 Aug 16;172(2):313–326. doi: 10.1007/s10549-018-4920-x

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© The Author(s) 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 2 — Overall improvement of estrogen receptor assessment. Colour code for categories of receptor assessment: red: receptor positive (+), beige: receptor status inconclusive, blue: receptor negative (−). Note that the category ‘inconclusive’ for IHC in fact means that the IHC estimate is missing. Left sidebar of Sankey diagram: number of patients classified on basis of ‘IHC only’ (red: ER⁺, beige: ER^inc, blue: ER⁻). Right sidebar of Sankey diagram: number of patients classified when considering joint information from IHC, expression of the receptor gene GE, (ESR1) and the co-gene, CO, (AGR3). Flows from left (‘IHC only’) to right (IHC & GE & CO) are coloured according to their final category. Numbers of patients are given together with labels of flows (a–i)