Table 4.

Univariate and multivariate Cox proportional analysis regarding cancer-specific survival

Parameter	Univariate analysis		Multivariate analysis
	HR (95% CI)	p-value	HR (95% CI)	p-value
Age at diagnosis(years)
Continuous rise per year	0.98 (0.99–1.02)	0.412	0.93 (0.73–1.19)	0.574
Gender
Female	1 (reference)	0.488	1 (reference)	0.248
Male	1.07 (0.84–1.34)		1.15 (0.90–1.45)
Chemotherapy
No	1 (reference)	<0.001	1 (reference)	<0.001
Yes	0.32 (0.242–0.398)		0.32 (0.24–0.43)
CA19-9 elevated
No	1 (reference)	0.001	1 (reference)	0.035
Yes	1.46 (1.16–1.83)		1.29 (1.02–1.64)
Amylase
<20 U/l	1 (reference)	0.039	1 (reference)	0.034
≥20 U/l	1.29 (1.01–1.57)		1.40 (1.03–1.92)
Lipase
<36 U/l	1 (reference)	0.039	1 (reference)	0.689
≥36 U/l	1.38 (1.01–1.56)		0.94 (0.69–1.23)
Karnofsky index
<80	1 (reference)	<0.001	1 (reference)	0.314
90–100	0.67 (0.54–0.84)		0.88 (0.69–1.13)
Creatinine (continuous)	1 (reference) 1.00 (0.99–1.02)	0.483	1 (reference) 1.01 (0.97–1.02)	0.176

HR hazard ratio, CI confidence interval