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. 2018 Oct 26;11:2577–2586. doi: 10.2147/JPR.S169686

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© 2018 Zhang et al. This work is published and licensed by Dove Medical Press Limited

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Riluzole reduces the hyperexcitability of SDH neurons in a slice model of disinhibition.

Notes: (A) DR stimulation at C-fiber intensity evoked a biphasic response in a lamina II neuron. (B) The application of bicuculline (2 µM) and strychnine (20 µM) successfully blocked the IPSPs and generated long-lasting repetitive action potentials. (C) Riluzole (50 µM) totally suppressed bicuculline- and strychnine-induced action potentials. HP was clamped at −50 mV in current clamp mode.

Abbreviations: SDH, superficial dorsal horn; DR, dorsal root; IPSP, inhibitory postsynaptic potential; HP, hold potential.