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Efficacy of lurbinectedin by dose. A waterfall plot shows the maximum variation of target lesions in patients with at least one radiologic tumor assessment in arm A (BRCA1/2) and arm B (BRCA wild-type or unknown status). One patient in arm B had a complete response in target lesions but not in nontarget lesions (objective response was then partial). (*) Confirmed response. (†) Patients with BRCA2 mutation. FD, flat dose; PR, partial response; PD, disease progression.
