Table 5.
SOF and MrOS Cognitive Decline Analyses.
| Gene | CHR | BP Start | BP Stop | # SNPs | Test Statistic | P Value | |
|---|---|---|---|---|---|---|---|
| SOF cognitive decline analysis | GABRG1 | 4 | 45732543 | 45820839 | 147 | 612.0 | 6.78 × 10−3 |
| GNG2 | 14 | 51396799 | 51506268 | 365 | 819.2 | 7.93 × 10−3 | |
| PPP2R5E | 14 | 62911107 | 63079832 | 172 | 563.6 | 9.43 × 10−3 | |
| GABRA2 | 4 | 45946338 | 46086813 | 146 | 722.7 | 9.88 × 10−3 | |
| KCNJ14 | 19 | 53650577 | 53661179 | 37 | 107.2 | .012 | |
| RAF1 | 3 | 12600099 | 12680700 | 116 | 351.2 | .017 | |
| SLC6A13 | 12 | 200051 | 242263 | 130 | 305.1 | .017 | |
| GRIK5 | 19 | 47194312 | 47261797 | 25 | 71.5 | .020 | |
| HTR4 | 5 | 147810787 | 148013934 | 234 | 623.6 | .020 | |
| SLC38A2 | 12 | 45038237 | 45052814 | 52 | 202.8 | .021 | |
| KIF5C | 2 | 149349288 | 149591519 | 145 | 402.0 | .022 | |
| GNG10 | 9 | 113463681 | 113472347 | 87 | 208.8 | .029 | |
| GNG4 | 1 | 233777607 | 233880677 | 135 | 275.0 | .040 | |
| MrOS cognitive decline analysis | GRIA2 | 4 | 158361185 | 158506676 | 107 | 553.2 | 5.40 × 10−4 |
| ADCY3 | 2 | 24895541 | 24995559 | 190 | 891.8 | 2.59 × 10−3 | |
| GNG12 | 1 | 67939736 | 68071730 | 234 | 733.6 | 6.36 × 10−3 | |
| HTR1E | 6 | 87704128 | 87783116 | 144 | 430.6 | .010 | |
| GNAL | 18 | 11679264 | 11871919 | 245 | 565.4 | .012 | |
| DRD4 | 11 | 627304 | 630703 | 44 | 119.3 | .018 | |
| KCNQ2 | 20 | 61507985 | 61574437 | 85 | 173.3 | .028 | |
| GRIA4 | 11 | 104986009 | 105358029 | 377 | 794.7 | .036 | |
| CALY | 10 | 134988917 | 135000465 | 54 | 112.0 | .040 | |
| SHANK1 | 19 | 55856895 | 55912007 | 63 | 116.7 | .042 | |
| KCNN2 | 5 | 113725914 | 113860096 | 242 | 499.1 | .043 | |
| GABRG2 | 5 | 161427225 | 161515123 | 129 | 271.9 | .046 | |
| HTR3E | 3 | 185300660 | 185307477 | 63 | 139.4 | .048 |
Abbreviations: CHR, chromosome; BP, base position; MrOS, Osteoporotic Fractures in Men; SNP, single nucleotide polymorphism; SOF, Study of Osteoporotic Fractures; VEGAS, Versatile Gene-Based Association Study.