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. 2018 Oct 31;13(10):e0206256. doi: 10.1371/journal.pone.0206256

Fig 1. Higher frequencies of LAG-3, PD1, TIGIT and TIM3 on CD4 and CD8 T cells in ART naïve group.

Fig 1

Checkpoint inhibitor (CPI) molecules and T cell immune activation markers were analyzed on CD4 and CD8 T cells by flow cytometry in ART naïve (Gp1) and virologically suppressed (Gp2) patients and healthy controls (Gp3). A), Representative flow cytometry dot plots showing gating strategy for the analysis of CPI on CD4 T cells. Frequencies of LAG-3+, PD1+, TIGIT+, and TIM3+ cells are shown in B), for CD4 T cells and C), for CD8 T cells. Line and error bars within the plot indicate the Mean ± SD. Data compared between groups using Wilcoxon rank-sum test. A p value <0.05 was considered significant. *p<0.05; **p<0.01; ***p<0.001; ****p<0.0001.