Table 2. Correlations between LAG-3, PD1 and LAG-3+PD1+ expressing CD4 T cells and cardiac function.

Cardiac function	CD4+LAG 3+ (%)		CD4+PD1+ (%)		CD4+LAG 3+ PD1+ (%)
Gp1 (ART Naïve)	p value	r value	p value	r value	p value	r value
Cardiac ejection time	0.001	-0.33	0.001	-0.33	<0.0001	-0.4
Cardiac output	<0.0001	-0.38	0.001	-0.33	<0.0001	-0.42
Cardiac index	<0.0001	-0.4	<0.0001	-0.39	<0.0001	-0.45
Stroke volume	0.001	-0.33	0.005	-0.29	<0.0001	-0.39
Stroke volume index	<0.0001	-0.34	0.001	-0.33	<0.0001	-0.41
Systemic vascular-resistance	0.0002	0.38	0.0005	0.36	0.0001	0.39
Large artery elasticity	NS	-	NS	-	0.03	-0.23
Gp2 (Virologically suppressed)
systemic vascular-resistance	0.009	0.21	0.03	0.17	0.008	-0.21
Large artery elasticity	0.009	-0.21	0.01	-0.21	<0.0001	-0.19
Small artery elasticity	0.001	-0.26	NS	-	0.03	-0.17

Cardiac function and vascular measures were correlated with LA-G3+, PD1+ and LAG-3 plus PD1+ CD4 T cells using Pearson correlation. Data are shown for correlation coefficient (r) and significance (p). A p value of <0.05 was considered significant.