Table 3. Correlations between LAG-3, PD1 and LAG-3+PD1+ expressing CD8 T cells and cardiac function.
| Cardiac function | CD8+LAG 3+ (%) | CD8+PD1+ (%) | CD8+LAG 3+PD1+ (%) | |||
|---|---|---|---|---|---|---|
| Gp1 (ART Naïve) | p value | r value | p value | r value | p value | r value |
| Cardiac ejection time | 0.023 | -0.22 | 0.005 | -0.28 | 0.0003 | -0.36 |
| Cardiac output | 0.002 | -0.30 | 0.017 | -0.24 | 0.002 | -0.31 |
| Cardiac index | 0.004 | -0.28 | 0.013 | -0.24 | 0.002 | -0.31 |
| Stroke volume | 0.013 | -0.24 | 0.007 | -0.27 | 0.0006 | -0.34 |
| Stroke volume index | 0.013 | -0.28 | 0.004 | -0.28 | 0.0005 | -0.35 |
| Systemic vascular-resistance | 0.017 | 0.24 | NS | - | NS | - |
| Large artery elasticity | NS | - | NS | - | 0.004 | -0.3 |
| Gp2 (Virologically suppressed) | ||||||
| systemic vascular-resistance | 0.009 | 0.21 | NS | - | NS | - |
| Large artery elasticity | 0.021 | -0.17 | 0.036 | -0.16 | NS | - |
| Small artery elasticity | 0.001 | -0.25 | NS | - | NS | - |
Cardiac function and vascular measures were correlated with LAG-3+, PD1+ and LAG-3+plus PD1+ CD8 T cells using Pearson correlation. Data are shown for correlation coefficient (r) and significance (p). A p value of <0.05 was considered significant.