Figure 2.

IgG molecules entrapped within a degradable hydrogel. (A) The IgG molecules are encapsulated by means of physical entrapment. (B) Entrapped IgG molecules are covalently linked to the hydrogel. (C) Release of encapsulated IgG molecules (physically entrapped) versus time. Burst release (of IgG in this case) occurs when biomolecules are encapsulated within hydrogels (A). (D) Release of encapsulated IgG molecules that were covalently linked to the hydrogel. The burst release was delayed when the antibodies were linked to the hydrogel by means of covalent bonds using bifunctional PEG molecules (B). Adapted and reproduced with permission from [129].