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. Author manuscript; available in PMC: 2018 Oct 31.
Published in final edited form as: J Intensive Care Med. 2011 Jan-Feb;26(1):3–12. doi: 10.1177/0885066610395678

Table 1.

Overview of IL-6 Actions

Acute phase response
Hypothalamic-pituitary-adrenal axis
 Fever
 Hormone release
Immune cell maturation and activation
 Immunoglobulin production by B cells
 Proliferation and differentiation of T cells
Hemostasis
 Platelet production from megakaryocytes
Hematopoesis
Endothelial cell activation
Neuronal cell differentiation
Keratinocyte proliferation
Cardiac muscle hypertrophy
Osteoclast activation

Abbreviation: IL-6, interleukin-6.