. Author manuscript; available in PMC: 2018 Oct 31.

Published in final edited form as: J Intensive Care Med. 2011 Jan-Feb;26(1):3–12. doi: 10.1177/0885066610395678

Table 2.

Overview of Actions of Several Members of the IL-6 Cytokine Family^a

IL-11	OSM	LIF
Acute phase response	Acute phase response	Acute phase response
Neurogenesis	Megakaryocyte differentiation	Neuronal survival factor
Hematopoiesis	Adhesion molecule expression	Hematopoiesis
Immune cell development	Mediates wound healing	Bone metabolism
Bone metabolism
CNTF	CT-I	CLC
Acute phase response	Acute phase response	Neuronal support
Activates acetylcholine transferase in motor neurons	Neuronal survival factor	Embryogenesis
	Increases platelet and erythrocyte counts
Anti-apoptotic effects after nerve injury	Cardiac myocyte hypertrophy
IL-27	IL-31	NP
Pro- and anti-inflammatory activities on white blood cells	Role in skin inflammation	Nervous system development in rodents
	Role in bronchopulmonary inflammation

Abbreviations: IL, interleukin; CNTF, ciliary neurotrophic factor; OSM, Oncostatin M; CT-1, cardiotrophin-1; LIF, leukemia inhibitory factor; CLC, cardiotrophin-like cytokine; NP, neuropoetin/cardiotrophin 2.

Modified from Biochem J. 1998; 334(pt 2): 297–314.³⁰