Skip to main content
. Author manuscript; available in PMC: 2019 Nov 1.
Published in final edited form as: Trends Cancer. 2018 Sep 28;4(11):741–754. doi: 10.1016/j.trecan.2018.09.004

Figure 2. GPC3 Inhibits Hedgehog Signaling by Competing with Patched for Hh Binding.

Figure 2.

GPC3 binds to Shh and Ihh with high affinity. LRP1 promotes glypican-3/Hh complex internalization in a HS dependent way. The internalized Hh is transported to lysosome for degradation. Therefore, patched without Hh binding inhibits Smoothened activation and blocks Hedgehog signaling.