Table 2. Linear mixed model analysis of the effect of baseline number of HF on baseline values of VA and CRT, and VA and CRT changes.

	Univariable			Multivariable
	Estimate	95% CI	P	Estimate	95% CI	P
CRT baseline, μm	-1.89	-5.71–1.94	0.325	-3.54	[-7.44–0.366]	0.074
CRT change, μm	-2.47	-4.64 –-0.31	0.026*	-2.61	[-4.42–0.79]	0.006*
VA baseline, logMAR	0.013	0.004–0.023	0.008*	0.008	[0.001–0.016]	0.047*
VA change, logMAR	-0.002	-0.009–0.004	0.473	-0.002	[-0.006–0.009]	0.661

Multivariable analyses were corrected for gender, age, duration of DME, DR stage, presence of cysts, presence of subretinal fluid, disruption of the external limiting membrane, disruption of the photoreceptor layer and the presence of disorganization of the retinal inner layers. Analyses of CRT and VA changes were also corrected for both CRT baseline and VA baseline. Analysis of CRT baseline was also corrected for VA baseline, and analysis of VA baseline was also corrected for CRT baseline.

CI = confidence interval; HF = hyperreflective foci; CRT = central retinal thickness

*P<0.05.