Fig. 2.
Ws-Lynx1 and JNK inhibition cancels the decrease in Lynx1 expression in a primary culture of cortical neurons treated with Aβ1-42. (A) Effect of Aβ1-42, Aβ42-1, and ws-Lynx1 on Lynx1 expression. (B) Effect of Aβ1-42, JNK inhibition by SP600125, and knockdown of the JNK1 and JNK2 genes on Lynx1 expression. The data are presented as % of the control ± s.e.m. (n = 4). Data indicated by * (p < 0.05), ** (p < 0.01), and **** (p < 0.0001) mean a statistically significant difference between groups according to the one-sided ANOVA test, followed by the Tukey’s/hoc test. (C) Schematic structure of the Lynx1 gene. Red lines denote the c-Jun and c-Fos binding sites.