Table 1.

Malignancies in the p53^+/- irradiation model.

No.	p53 geno-type	WASp genotype	Death after irradiation (weeks)	Histology	Macro-scopically ulcerating	Spleno-megaly	Tumor infiltration of CD45+ (FACS)
A) Spindle cell tumors
46B	+/-	+	9	Cystic hair follicle dilatation with large numbers of F4/80+ spindle shaped atypical cells in surrounding dermis	NO	YES	N/A
89C	+/-	+	13	Spindle tumor, malignant, NOS; up to 8 mit/40x. Ulcerated. Extensive F4/80 positivity in spindle cell tumor area.	YES	NO	low myeloid
135A	+/-	+	24	Spindle tumor, malignant, NOS; up to 10 mit/40x. Ulcerated. Extensive F4/80 positivity in spindle cell tumor area.	YES	YES	N/A
87A	+/-	-	6	Spindle tumor, malignant, NOS. Neutrophils are present in the necrotic area, but the tum. is not heavily infiltrated.	YES	YES	high myeloid
89A	+/-	-	8	Subcut. abcess overlying lymphnode. Marked F4/80+ spindle cell proliferation in surroundings, neovascularisation. Neutrophils are associated with the abscess with puss.	NO	YES	high myeloid SP,BL: CD11b exp.
83B	+/-	XLN (I296T)	22	Spindle tumor, malignant, NOS; up to 6 mit/40x. Ulcerated. Extensive F4/80 positivity in spindle cell tumor area. Neutrophils are abundant in the tumor mass even far from the ulceration.	NO	YES	low myeloid+
105C	+/-	XLN (L272P)	13	Spindle tumor, malignant, NOS; up to 5 mit/40x. Extensive F4/80 positivity in spindle cell tumor area. Neutrophils are rare and they are not appear to be the integral part of tumor mass.	NO	NO	Low SP: CD11b exp.
49B	+/+	+	23	Spindle tumor, malignant, NOS; up to 5 mit/40x. Extensive F4/80 positivity in spindle cell tumor area.	NO	NO	N/A
No.	p53 geno-type	WASp genotype	Death after irradiation (weeks)	Histology	Enlargedthymus	Spleno-megaly	Hematopoietic infiltration (FACS)
B) Lymphomas
119A	+/-	+	24	N/A	YES	YES
123A	+/-	+	9	Neoplastic, lymhoid infiltr. of BM,LN,SPL, liver and lung	NO	YES	LIV: High T cell infiltr. BL: T norm, B lymphopeina
124A	+/-	+	12	Hematopoietic neoplasm	NO	YES	LIV: T cell SP,BL: T cell exp.
78A	+/-	-	24	Lymphoma	YES	YES	LIV: T cell exp.
118A	+/-	-	22	Lymphoma	YES	NO	LIV: T cell exp. SP:CD34+ exp.
65B	+/-	XLN(I296T)	18	High grade lymphoblastic lymphoma	YES	YES
84B	+/-	XLN(I296T)	20	N/A	YES	N/A
101C	+/-	XLN(L272P)	18	N/A	YES	NO
No.	p53 geno-type	WASp genotype	Death after irradiation (weeks)	Histology	Cause of death	Spleno-megaly	Hematopoietic infiltration (FACS)
C) Mixed hematopoietic proliferation
44C	+/-	+	15	LIV: enlarged, white dotted LIV, SP, BM: hematopietic expansion LIV: Large numbers of F4/80+ cells Disseminated histiocytic neoplasm?	Severe weightloss	YES	LIV: T cell (CD3+) and myeloid (CD11b+) infiltration SP: T,B compartments are replaced by lin-(CD3-CD19-CD11b-) cells BL: T,B lymphopenia
117C	+/-	+	24	Pre-neoplastic? SP,BM: myeloid proliferation	EP	YES	LIV: T cell (CD3+) and myeloid (CD11b+) infiltration SP: norm.
111A	+/-	-	24	Pre-neoplastic? SP,LIV: mixed proliferation of hematopoietic components, probably lymphocytes and macrophages. SP,BM: myeloid proliferation	EP	YES	Myeloid infiltraton in liver SP: T,B compartments are replaced by lin-(CD3-CD19-CD11b-) cells
114A	+/-	-	10	LIV, LN: mainly lymphopblastic proliferation with myeloid components	Severe weightloss	YES	LIV (pale col.): High myeloid (CD11b+) expansion. T,B exp. SP: T,B compartments are replaced by lin-(CD3-CD19-CD11b-) cells BL (pale color): very high myeloid counts, T,B lymphopenia
No.	p53 geno-type	WASp genotype	Death after irradiation (weeks)	Histology	Cause of death	Spleno-megaly	Hematopoietic infiltration (FACS)
D) Unknown
101A	+/-	-	18	Large abscess on skin; reactive expansion of myeloid lineage?	Prolif.	YES
153A	+/-	-	5	N/A	Severe weightloss	N/A