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. 2018 Oct 25;27(21):1494–1506. doi: 10.1089/scd.2018.0124

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© Sofieke E. Klamer et al. 2018; Published by Mary Ann Liebert, Inc.

This Open Access article is distributed under the terms of the Creative Commons License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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FIG. 3. — TGFBI knockdown in HSPCs reduces total proliferation of HSPCs. HSPCs with TGFBI knockdown (A, C) or TGFBI overexpression (B, D) were cultured in maintenance cocktail and enumerated and analyzed for AnnexinV exposure by flow cytometry 10 days posttransduction. (A) HSPCs show decreased cell numbers upon TGFBI knockdown (n = 5). (B) No significant effect on HSPC numbers was observed upon TGFBI overexpression (n = 4). (C) TGFBI knockdown (n = 5) or (D) TGFBI overexpression (n = 4) did not give a significant effect on AnnexinV exposure in HSPCs. Shown are mean ± SEM. *P < 0.05, NS indicates P-value nonsignificant, sh2/sh3 indicates that sh2 or sh3 was used in independent experiments. SCR indicates that a scrambled shRNA control was used. SEM, standard error of the mean.