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Hydrogels were synthesized containing either CYKC or a 1:1 ratio of CGGYC and CGKC. The CYKC peptide can be cleaved by either chymotrypsin or trypsin, producing an OR gate. In the latter hydrogel, the CGGYC is cleaved by chymotrypsin and the CGKC is cleaved by trypsin; therefore, both enzymes must be present for a blueshift response to occur.
