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. Author manuscript; available in PMC: 2019 Oct 31.
Published in final edited form as: J Am Chem Soc. 2018 Oct 16;140(43):14440–14454. doi: 10.1021/jacs.8b09223

Figure 18.

Figure 18.

Top: Assay for stimulated TNF-α release upon treatment with 3 (500 nM) using macrophages from mice containing disabling germline mutations or knockouts of genes encoding key mTLRs and downstream signaling proteins. Bottom: Assay for stimulated TNF-α release upon treatment with 3 (250 pM) versus controls without compound using differentiated THP-1 cells that is blocked by antibodies that bind either TLR1 or TLR2. All results are representative of two independent experiments and error bars represent SEM.