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. Author manuscript; available in PMC: 2019 Oct 31.
Published in final edited form as: J Am Chem Soc. 2018 Oct 16;140(43):14440–14454. doi: 10.1021/jacs.8b09223

Figure 4.

Figure 4.

Compounds that established the importance of the presence and number of 2-phenylcyclopropylamine residues derived from active lead (10) in plate 39G9. EC50’s derived from dose-response curves for the stimulated release of TNF-α from differentiated THP-1 cells or mouse macrophages by 8–12.